A must see in the Eastern Sierra is Thousand Island Lake just outside of the town of Mammoth Lakes, nestled underneath the Ritter Range, and Lyell Canyon in Yosemite National Park. Our Mammoth Lakes to Tuolumne Meadows 5 day backpacking trip will take you past breathtaking lakes, gorgeous meadows, and stunning canyons as you head north towards Yosemite National Park. If you’re looking for a must do backpacking trip in the Eastern Sierra, then this is the trip for you!